"Music daunting complexity reverberates in its beauty and in the countless, powerful properties that can transform our lives."


In the past 20 years, the perception of music’s potential as a medical resource has undergone a profound transformation. MET - Music Education Therapy™ has introduced the element of music analysis and strict correlation with psychophysiological parameters. Genote is dedicated to studying, researching and promoting innovative technologies for the application of all rigorous scientific findings in the correlation between music and health.

Genote's implementation technology and proprietary method of analyzing, selecting and clinically testing music content make Health Music™simple to adopt in studies on clinical and musical outcomes, whether for individuals or groups in controlled environments or everyday life.

The following abstracts represent Genote research findings in different settings and populations. The list includes abstracts from papers, program evaluations, observational studies, and single case studies.



A Randomized Study of Music Education Therapy™ (MET) compared to Standard Care for the Treatment of Acute Post-Operative Pain in Term and Near-Term Neonates (current)

The primary Objective of this project is to demonstrate the efficacy of Music Education Therapy™ (MET) plus standard of care (SOC) acetaminophen and opioids [SOC] for the relief of moderate to severe acute pain in neonates > to 34 weeks EGA compared to SOC (Control Group), as indicated by a reduction in opioid consumption and NPASS pain scale scoring. Additional evaluation of pain response will include blood pressure, heart rate, respiratory effort and oxygen saturation level. Also, time to extubation, time to full feeds and assessment prior to discharge Brazelton™ NBA tool will be evaluated.


Effectiveness of Genote as a therapeutic aid in a Residential Treatment Center (current)

The objective of the study is to evaluate the effectiveness of Genote in the life, learning and therapeutic cycles of students in a residential treatment center. Evaluations of the program efficacy and observation will be measured through psycho-behavioral assessment by clinical staff and through self-assessed survey during a period of 4 weeks through online tools before and after listening of structured music protocols.


Genote Effectiveness Study on Special Education (completed)

The project was formulated to support and enrich the educational experience, improve health outcomes and quality of life of the students affected by multiple disabilities while at school and at home. The three main categories that were analyzed are: teachers’ observations, parents’ observations and the students' reaction to the music. Data analysis shows statistical significance in various parameters such as mood, focus, the ability to fall asleep, and sleep consistency. Comfort levels and behavioral states also saw improvement after the music intervention. The findings suggest that the implementation of Genote produces noteworthy benefits in all target areas.


Observational Report: Evaluation of the effects of Genote while recovering during a professional cycling competition (BMC USA Cycling Team at the 2015 Tour De France - completed)

The BMC USA cycling team were equipped with Genote protocols, before commencing the cycling competition (Tour the France). Each athlete was asked to listen to a structured music protocol before going to bed every night during the three-week competition. Method efficacy was assessed by the increment of the athletes that adopted and listened to Genote music from beginning to end. Intervention efficacy evaluated by the medical director, shows an improvement in the length of perceived quality and depth of sleep. Recovery outcome was deemed positive by observational assessment by the medical director.


The effect of a Structured Music Listening Protocol on pain during pic hill stick in a ICU level 3° (completed)

The study aims to demonstrate the beneficial effect of a Structured Music Protocol on vital functions and the perception of pain in the course of puncturing the heel to the collection of blood for metabolic tests that are performed routinely at the 36th hour of life in infants admitted to the Neonatal Care department. There were no statistically significant differences with regard to the FC of the two populations both before and after the puncture and squeezing of the heel. If, however, is considered a possible placebo effect related to the controlled conditions of the study in the control population, there is a statistically significant difference both at baseline and in minutes after heel stick.


Effects of Structured Music Listening Protocol to Promote Quiet Sleep in Alzheimer Patients (completed)

Through a comparative descriptive study conducted in a Level II, lock-down facility, patient’s quality of sleep, and overall quality of life improved significantly. The experimental group listened to a Structured Music Protocol in a controlled environment and dedicated sound system. Nurses, technicians and patients’ relatives observed a significant increase in participation during daily activities. Positive reaction to project implementation from personnel and strong acceptance from family members. Compliance levels were significantly higher than previous palliative care projects.


Randomized Controlled Study: Evaluation of the effects of Genote as a recovery tool during training for long distance runners (Running Team 2013 Venice Marathon - completed)

Through a full month of training, 30 athletes were equipped with the Genote platform. All athletes were under the care of the Venice Dolo Hospital's Sports Medicine Director, who, after routine blood work, was able to evaluate CK, Hb, Cortisol, and Testosterone levels. Each athlete completed a daily quantitative questionnaire to determine energy levels, coping skills, motivation, and recovery over the four-week period. Significant outcomes show a decrease of CK, increase of Testosterone and better motivational and coping skills.


Randomized Controlled Study: Evaluation of the effects and feasibility of a music protocol (MET) to promote quiet sleep in neurologically healthy newborns while treated in NICU (completed)

The primary target of this QI Pilot Project is to demonstrate the efficacy of Music Education Therapy™ (MET) on sixteen newborns > 31 weeks’ gestational age. The experimental group listened to half hour-twice/day to Structured Music Listening Protocols with controlled sound level. Principal evaluation of response included blood pressure, heart rate, respiratory effort and oxygen saturation level. Also, time between transition of behavioral states. Results and observational evaluation show significant improvement of transition of behavioral states (Brazelton™ NBA); continued deep sleep (no overstimulation) and improved vital parameters stabilization with no desaturation events.


Observational Report: Evaluation of the effects of a music intervention (MET) to promote personnel satisfaction (completed)

Research indicates that up to 40% of U.S. health care professionals experience emotional, physical, and psychological burnout from their jobs. A full medical ICU staff was equipped with Genote for a quality improvement project. The study evaluates the feasibility, effects on workflow, staff acceptance, and satisfaction of Music Education Therapy methodology.


Evaluation of a Structured Music Program for Adolescents with Behavioral Problems

A two-year comparative descriptive study with more than 6000 hours of recorded activities of adolescent students (n=125). The study was conducted by a therapeutic team of psychologists, music specialists, teachers, recreational therapists, student life coordinators, psychiatrics and a nurse during 2004-2005 to investigate the utility of a daily music education intervention structured to three settings (i.e. choir rehearsal, music aesthetics, and group therapy) offered throughout the day at two private college prep schools for the 9-month school year. As the program advanced, the initial topic of discussion and analysis was broadened. During the recorded activities, various behavioral responses were taken into consideration and associated with specific music content. The process of emotional alphabetization through music education resulted in a defined library of musical selections that responded to specific inputs, therapeutic needs and responses. Is clear that further examination is needed. A strict correlation between music exposure and mood modification was established.


Single Cases Studies and Observations

Through years of testing, research and implementation, the Genote team has collected a high number of single cases studies and observational materials from people with different challenges, age and conditions. These cases have been recorded to enrich our knowledge, formulate new hypothesis and further scientific and music knowledge of the correlation between music and medicine. The Genote team owes a great debt to the individuals that have entrusted their lives, troubles and hopes to our scientific research.


Current and Future Studies

Genote, through its proper channels, collaborates with international scientific partners to evaluate and further discover music research's therapeutic value. By rigorous application of high scientific and artistic standards, thousands of physicians and patients have been introduced Genote; many have greatly benefitted from its music library. To learn more about our current international research, or to receive a copy of published material, please write to desk@genotelab.com.